DEVELOPMENT OF CHICKEN EGG WHITE AND MUPIROCIN LOADED HYDROGEL DRESSING MATERIAL FOR INHIBITION OF BACTERIAL GROWTH
First of all, thanks to ALLAH to whom I relate my success in this thesis work. I have no words to thank my supervisor, Lieutenant Colonel Md. Maruf Hasan, PhD for guiding me throughout this project and for his great help, advice, and encouragement. I would like to thank Colonel Syed Mahfuzur Rahm...
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | Tesis |
| Lenguaje: | inglés |
| Publicado: |
Department of Biomedical Engineering, MIST
2024
|
| Materias: | |
| Acceso en línea: | http://dspace.mist.ac.bd:8080/xmlui/handle/123456789/824 |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1868227067788656640 |
|---|---|
| author | NAIM, ZANNATUL |
| author_browse | NAIM, ZANNATUL |
| author_facet | NAIM, ZANNATUL |
| author_sort | NAIM, ZANNATUL |
| collection | DSpace |
| description | First of all, thanks to ALLAH to whom I relate my success in this thesis work. I have no
words to thank my supervisor, Lieutenant Colonel Md. Maruf Hasan, PhD for guiding me
throughout this project and for his great help, advice, and encouragement.
I would like to thank Colonel Syed Mahfuzur Rahman, Head of the Department of
Biomedical Engineering (BME) at the Military Institute of Science and Technology
(MIST) for his outstanding support and encouragement during my thesis defense.
I am also thankful to S. M. Masud Rana previous M.Sc. Engg. student of the BME
Department, MIST and present Assistant Manager (Production Pharmacist) of The
ACME Laboratories Ltd. Dhamrai, Dhaka, Bangladesh, and Shammi Quraishi previous
B.Sc. Engg. student of the same department and present student in the Master’s program
of Biomedical and Science and Engineering at the University of Tampere, Finland for
outstanding support throughout the thesis project.
I would like to thank the Department of BME, MIST, Dhaka, Bangladesh for overall
support and the Bangladesh University of Engineering and Technology (BUET), Dhaka,
Bangladesh for providing Scanning Electron Microscope (SEM) and Fourier Transform
Infrared Spectroscopy (FTIR) support.
I am truly obliged to the rest of the Board of Examination members for reviewing this
thesis and giving support, suggestions, and valuable time. I would especially like to thank
the external member of the Board of Examination Prof. Dr. Muhammad Tarik Arafat,
Head of the BME Department of BUET, Dhaka, Bangladesh for his intellectual inputs
and valuable suggestions.
Additionally, I am also grateful to Dr. Md. Asadur Rahman, Assistant Professor and
Postgraduate Course Coordinator of the BME Department at MIST for his outstanding
support.
At last, I would like to thank my family that consistently supported and motivated me
towards achieving my goal, particularly to my little new family member, little angel and
princess my daughter ‘RUHAMA’ who was born just nineteen days after my thesis
defense. Since then, she has been an encouragement and inspiration in a great deal. |
| format | Thesis |
| id | oai:localhost:123456789-824 |
| institution | My University |
| language | English |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Department of Biomedical Engineering, MIST |
| publisherStr | Department of Biomedical Engineering, MIST |
| record_format | dspace |
| spelling | oai:localhost:123456789-8242024-06-11T06:08:10Z DEVELOPMENT OF CHICKEN EGG WHITE AND MUPIROCIN LOADED HYDROGEL DRESSING MATERIAL FOR INHIBITION OF BACTERIAL GROWTH NAIM, ZANNATUL Development of Chicken Egg White and Mupirocin Loaded Hydrogel Dressing Material for Inhibition of Bacterial Growth First of all, thanks to ALLAH to whom I relate my success in this thesis work. I have no words to thank my supervisor, Lieutenant Colonel Md. Maruf Hasan, PhD for guiding me throughout this project and for his great help, advice, and encouragement. I would like to thank Colonel Syed Mahfuzur Rahman, Head of the Department of Biomedical Engineering (BME) at the Military Institute of Science and Technology (MIST) for his outstanding support and encouragement during my thesis defense. I am also thankful to S. M. Masud Rana previous M.Sc. Engg. student of the BME Department, MIST and present Assistant Manager (Production Pharmacist) of The ACME Laboratories Ltd. Dhamrai, Dhaka, Bangladesh, and Shammi Quraishi previous B.Sc. Engg. student of the same department and present student in the Master’s program of Biomedical and Science and Engineering at the University of Tampere, Finland for outstanding support throughout the thesis project. I would like to thank the Department of BME, MIST, Dhaka, Bangladesh for overall support and the Bangladesh University of Engineering and Technology (BUET), Dhaka, Bangladesh for providing Scanning Electron Microscope (SEM) and Fourier Transform Infrared Spectroscopy (FTIR) support. I am truly obliged to the rest of the Board of Examination members for reviewing this thesis and giving support, suggestions, and valuable time. I would especially like to thank the external member of the Board of Examination Prof. Dr. Muhammad Tarik Arafat, Head of the BME Department of BUET, Dhaka, Bangladesh for his intellectual inputs and valuable suggestions. Additionally, I am also grateful to Dr. Md. Asadur Rahman, Assistant Professor and Postgraduate Course Coordinator of the BME Department at MIST for his outstanding support. At last, I would like to thank my family that consistently supported and motivated me towards achieving my goal, particularly to my little new family member, little angel and princess my daughter ‘RUHAMA’ who was born just nineteen days after my thesis defense. Since then, she has been an encouragement and inspiration in a great deal. The bacterial infection of wound is one of the major challenges in wound care treatment. Topical antibiotic mupirocin is an antibacterial agent widely used to inhibit bacterial growth after wound formation in the human body. Antibacterial activity of egg white with wound healing capability also has been reported in research articles. Therefore, the hydrogel was prepared by incorporating chicken egg white and mupirocin into poly vinyl alcohol (PVA) and gelatin polymer matrix via solution casting method for the purpose of bacterial growth inhibition. The developed hydrogels were characterized by Fourier Transform Infrared Spectroscopy (FTIR) that confirmed the presence of a functional group of the different components in the hydrogel and crosslinking occurred by esterification process between PVA and gelatin by glutaraldehyde. The developed hydrogels were characterized morphologically by Scanning Electron Microscope (SEM), it showed a smooth break surface for neat hydrogel (NH) and chicken egg white loaded hydrogel (EH), smooth and homogenous surface for mupirocin loaded hydrogel (MH) and rough surface for mupirocin with chicken egg white loaded hydrogel (MEH). Moreover, swelling behavior in water, moisture retention capability, folding endurance, water vapor transmission rate (WVTR), pH determination, gel fraction, spreadability, and porosity tests were conducted to reveal the chemical and physical properties of the hydrogel. All the values obtained from these tests were compatible with the published data and to some extent with the commercially available products. Eventually, developed hydrogels were characterized biologically by the disc diffusion method to evaluate bacterial inhibition activity. MH and MEH showed significant inhibition against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa bacteria and EH showed moderate inhibition against experimented bacteria. This newly prepared chicken egg white and mupirocin-loaded hydrogel might play an important role in inhibiting the growth of bacteria during the wound healing process. Hence, current outcomes with experimental findings can be used for further investigation in future in vivo tests on mice models. 2024-06-11T06:08:10Z 2024-06-11T06:08:10Z 2023-03 Thesis http://dspace.mist.ac.bd:8080/xmlui/handle/123456789/824 en application/pdf Department of Biomedical Engineering, MIST |
| spellingShingle | Development of Chicken Egg White and Mupirocin Loaded Hydrogel Dressing Material for Inhibition of Bacterial Growth NAIM, ZANNATUL DEVELOPMENT OF CHICKEN EGG WHITE AND MUPIROCIN LOADED HYDROGEL DRESSING MATERIAL FOR INHIBITION OF BACTERIAL GROWTH |
| title | DEVELOPMENT OF CHICKEN EGG WHITE AND MUPIROCIN LOADED HYDROGEL DRESSING MATERIAL FOR INHIBITION OF BACTERIAL GROWTH |
| title_full | DEVELOPMENT OF CHICKEN EGG WHITE AND MUPIROCIN LOADED HYDROGEL DRESSING MATERIAL FOR INHIBITION OF BACTERIAL GROWTH |
| title_fullStr | DEVELOPMENT OF CHICKEN EGG WHITE AND MUPIROCIN LOADED HYDROGEL DRESSING MATERIAL FOR INHIBITION OF BACTERIAL GROWTH |
| title_full_unstemmed | DEVELOPMENT OF CHICKEN EGG WHITE AND MUPIROCIN LOADED HYDROGEL DRESSING MATERIAL FOR INHIBITION OF BACTERIAL GROWTH |
| title_short | DEVELOPMENT OF CHICKEN EGG WHITE AND MUPIROCIN LOADED HYDROGEL DRESSING MATERIAL FOR INHIBITION OF BACTERIAL GROWTH |
| title_sort | development of chicken egg white and mupirocin loaded hydrogel dressing material for inhibition of bacterial growth |
| topic | Development of Chicken Egg White and Mupirocin Loaded Hydrogel Dressing Material for Inhibition of Bacterial Growth |
| url | http://dspace.mist.ac.bd:8080/xmlui/handle/123456789/824 |
| work_keys_str_mv | AT naimzannatul developmentofchickeneggwhiteandmupirocinloadedhydrogeldressingmaterialforinhibitionofbacterialgrowth |