STRUCTURAL CHARACTERIZATION OF LEGIONELLOSIS DRUG TARGET CANDIDATE ENZYME PHOSPHOMANNOMUTASE FROM LEGIONELLA PNEUMOPHILA STRAIN PARIS: AN IN SILICO APPROACH
Md. Arif Khan[1] and Mohammad Neaz Morshed[2] 1, 2 Department of Chemistry, Military Institute of Science and Technology (MIST), Mirpur Cantonment, Dhaka 1216, Bangladesh. 1arifkhanbge35@gmail.com, 2mmneaz@hotmail.com
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2020
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| author | Khan, Md. Arif Morshed, Mohammad Neaz |
| author_browse | Khan, Md. Arif Morshed, Mohammad Neaz |
| author_facet | Khan, Md. Arif Morshed, Mohammad Neaz |
| author_sort | Khan, Md. Arif |
| collection | DSpace |
| description | Md. Arif Khan[1] and Mohammad Neaz Morshed[2]
1, 2 Department of Chemistry, Military Institute of Science and Technology (MIST),
Mirpur Cantonment, Dhaka 1216, Bangladesh.
1arifkhanbge35@gmail.com, 2mmneaz@hotmail.com |
| format | Article |
| id | oai:localhost:123456789-518 |
| institution | My University |
| language | English |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | R&D Wing, MIST |
| publisherStr | R&D Wing, MIST |
| record_format | dspace |
| spelling | oai:localhost:123456789-5182020-06-10T06:30:59Z STRUCTURAL CHARACTERIZATION OF LEGIONELLOSIS DRUG TARGET CANDIDATE ENZYME PHOSPHOMANNOMUTASE FROM LEGIONELLA PNEUMOPHILA STRAIN PARIS: AN IN SILICO APPROACH Khan, Md. Arif Morshed, Mohammad Neaz Legionella pneumophila, Legionellosis, homology modeling. 1.0 INTRODUCTION Md. Arif Khan[1] and Mohammad Neaz Morshed[2] 1, 2 Department of Chemistry, Military Institute of Science and Technology (MIST), Mirpur Cantonment, Dhaka 1216, Bangladesh. 1arifkhanbge35@gmail.com, 2mmneaz@hotmail.com The harshness of legionellosis differs from mild Pontiac fever to potentially fatal Legionnaire’s disease. The increasingdevelopment of drug resistance against legionellosis has led to explore new novel drug targets. It has been found thatphosphoglucosamine mutase, phosphomannomutase, and phosphoglyceromutase enzymes can be used as the mostprobable therapeutic drug targets through extensive data mining. Phosphomannomutase isconcerned in a process called glycosylation.The purpose of this study was to predict the potential target of that specific drug. For this,the 3D structure of Phosphomannomutase of Legionella pneumophila (strain Paris) was determined by means ofhomology modeling through Phyre2 and refined by ModRefiner. The designed model was evaluated with a structurevalidation program, for instance, PROCHECK, Verify3D, and QMEAN, for further structural analysis. Secondary structural features were determined through self-optimized prediction method with alignment (SOPMA) and interacting networks by STRING. The analytical result of PROCHECK showedthat 91.0% of the residues are in the most favored region, 8.50% are in the additional allowed region of the Ramachandran plot. Verify3D graph value indicates a score of 0.77 and 0.91 for QMEAN respectively. The findings of this current study along with further extensive investigation may assist drug design against Legionellosis. 2020-06-10T06:30:59Z 2020-06-10T06:30:59Z 2017-12 Article 2224-2007 http://hdl.handle.net/123456789/518 en application/pdf R&D Wing, MIST |
| spellingShingle | Legionella pneumophila, Legionellosis, homology modeling. 1.0 INTRODUCTION Khan, Md. Arif Morshed, Mohammad Neaz STRUCTURAL CHARACTERIZATION OF LEGIONELLOSIS DRUG TARGET CANDIDATE ENZYME PHOSPHOMANNOMUTASE FROM LEGIONELLA PNEUMOPHILA STRAIN PARIS: AN IN SILICO APPROACH |
| title | STRUCTURAL CHARACTERIZATION OF LEGIONELLOSIS DRUG TARGET CANDIDATE ENZYME PHOSPHOMANNOMUTASE FROM LEGIONELLA PNEUMOPHILA STRAIN PARIS: AN IN SILICO APPROACH |
| title_full | STRUCTURAL CHARACTERIZATION OF LEGIONELLOSIS DRUG TARGET CANDIDATE ENZYME PHOSPHOMANNOMUTASE FROM LEGIONELLA PNEUMOPHILA STRAIN PARIS: AN IN SILICO APPROACH |
| title_fullStr | STRUCTURAL CHARACTERIZATION OF LEGIONELLOSIS DRUG TARGET CANDIDATE ENZYME PHOSPHOMANNOMUTASE FROM LEGIONELLA PNEUMOPHILA STRAIN PARIS: AN IN SILICO APPROACH |
| title_full_unstemmed | STRUCTURAL CHARACTERIZATION OF LEGIONELLOSIS DRUG TARGET CANDIDATE ENZYME PHOSPHOMANNOMUTASE FROM LEGIONELLA PNEUMOPHILA STRAIN PARIS: AN IN SILICO APPROACH |
| title_short | STRUCTURAL CHARACTERIZATION OF LEGIONELLOSIS DRUG TARGET CANDIDATE ENZYME PHOSPHOMANNOMUTASE FROM LEGIONELLA PNEUMOPHILA STRAIN PARIS: AN IN SILICO APPROACH |
| title_sort | structural characterization of legionellosis drug target candidate enzyme phosphomannomutase from legionella pneumophila strain paris an in silico approach |
| topic | Legionella pneumophila, Legionellosis, homology modeling. 1.0 INTRODUCTION |
| url | http://hdl.handle.net/123456789/518 |
| work_keys_str_mv | AT khanmdarif structuralcharacterizationoflegionellosisdrugtargetcandidateenzymephosphomannomutasefromlegionellapneumophilastrainparisaninsilicoapproach AT morshedmohammadneaz structuralcharacterizationoflegionellosisdrugtargetcandidateenzymephosphomannomutasefromlegionellapneumophilastrainparisaninsilicoapproach |